Anti-ERBB2 Antibody

Rs. 61,689.00
SKU stj23556

General Information

Product name Anti-ERBB2 Antibody
Short Description Rabbit polyclonal to ERBB2
Description This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Applications WB,IHC,IF,FC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-ERBB2 Antibody
Immunogen A synthetic peptide of human ERBB2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 137.9 kDa
Database Links
Alternative Names ERBB2Receptor tyrosine-protein kinase erbB-2 ERBB2 antibodyHER2 antibodyMLN19 antibodyNEU antibodyNGL
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding, Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone, GP30 is a potential ligand for this receptor, Regulates outgrowth and stabilization of peripheral microtubules (MTs), Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane, In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Cellular Localization Cell membrane
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Swiss-Prot Key

 

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