Anti-ERBB3 Antibody

Rs. 45,619.00
SKU stj27534

General Information

Product name Anti-ERBB3 Antibody
Short Description Rabbit polyclonal to ERBB3
Description This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
Protein Name Anti-ERBB3 Antibody
Immunogen A synthetic peptide of human ERBB3
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 148.1 kDa
Database Links
Alternative Names ERBB3Receptor tyrosine-protein kinase erbB-3 ERBB3 antibodyHER3
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins, Binds to neuregulin-1 (NRG1) and is activated by it
Cellular Localization Cell membrane
Tissue Specificity Epithelial tissues and brain
Swiss-Prot Key

 

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