Anti-ERCC2 Antibody

Rs. 45,619.00
SKU stj27607

General Information

Product name Anti-ERCC2 Antibody
Short Description Rabbit polyclonal to ERCC2
Description The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-ERCC2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ERCC2 (NP_001124339.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 86.9 kDa
Database Links
Alternative Names ERCC2General transcription and DNA repair factor IIH helicase subunit XPD antibodyTFIIH subunit XPDERCC2 antibodyXPD antibodyXPDC
Function ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription, XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex, Involved in the regulation of vitamin-D receptor activity, As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, Might have a role in aging process and could play a causative role in the generation of skin cancers.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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