Anti-ERCC8 Antibody

Rs. 61,689.00
SKU stj28892

General Information

Product name Anti-ERCC8 Antibody
Short Description Rabbit polyclonal to ERCC8
Description This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
Protein Name Anti-ERCC8 Antibody
Immunogen A synthetic peptide of human ERCC8
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 44.1 kDa
Database Links
Alternative Names ERCC8DNA excision repair protein ERCC-8 antibodyCockayne syndrome WD repeat protein CSAERCC8 antibodyCKN1 antibodyCSA
Function Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair, The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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