Anti-ERLIN1 Antibody

Rs. 61,689.00
SKU stj26674

General Information

Product name Anti-ERLIN1 Antibody
Short Description Rabbit polyclonal to ERLIN1
Description The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-ERLIN1 Antibody
Immunogen A synthetic peptide of human ERLIN1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.9 kDa
Database Links
Alternative Names ERLIN1Erlin-1 antibodyEndoplasmic reticulum lipid raft-associated protein 1 antibodyProtein KE04 antibodyStomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 antibodySPFH domain-containing protein 1ERLIN1 antibodyC10orf69 antibodyKE04 antibodyKEO4 antibodySPFH1
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs), Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway, Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
Cellular Localization Endoplasmic reticulum membrane.
Tissue Specificity Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
Swiss-Prot Key

 

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