Anti-ERO1A Antibody

Rs. 68,577.00
SKU stj72561

General Information

Product name Anti-ERO1A Antibody
Short Description Goat polyclonal to ERO1A
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-ERO1A Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 54.4 kDa
Database Links
Alternative Names ERO1AERO1-like protein alpha antibodyERO1-L antibodyERO1-L-alphaERO1A antibodyERO1L antibodyUNQ434/PRO865
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum, Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation, Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell, Required for the proper folding of immunoglobulins, Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V,cholerae, thereby playing a role in retrotranslocation of the toxin, Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1,
Cellular Localization Endoplasmic reticulum membrane,
Tissue Specificity Widely expressed at low level, expressed at high level in upper digestive tract, highly expressed in esophagus, weakly expressed in stomach and duodenum,
Swiss-Prot Key

 

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