Anti-ERO1LB Antibody

Rs. 45,619.00
SKU stj26443

General Information

Product name Anti-ERO1LB Antibody
Short Description Rabbit polyclonal to ERO1B
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ERO1LB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 34-230 of human ERO1LB (NP_063944.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 53.5 kDa
Database Links
Alternative Names ERO1BERO1-like protein beta antibodyERO1-L-betaERO1B antibodyERO1LB
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum, Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation, Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%), Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell, May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
Cellular Localization Endoplasmic reticulum membrane.
Tissue Specificity Highly expressed in the digestive tract, including the duodenum and lower digestive tract, in the stomach, highly expressed in enzyme-producing chief cells (at protein level), in the pancreas, expressed in islets of langerhans and, at lower levels, in enzyme-secreting cells (at protein level), detected at low level in many other tissues.
Swiss-Prot Key

 

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