Anti-ETO-2 antibody

Rs. 50,211.00
SKU stj93008

General Information

Product name Anti-ETO-2 antibody
Short Description
Description Rabbit polyclonal to ETO-2.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-ETO-2 antibody
Immunogen Synthesized peptide derived from human ETO-2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 71.192 kDa
Database Links
Alternative Names Protein CBFA2T3 antibody
MTG8-related protein 2 antibody
Myeloid translocation gene on chromosome 16 protein antibody
hMTG16 antibody
Zinc finger MYND domain-containing protein 4 antibody
MTG16 antibody
MTGR2 antibody
ZMYND4 antibody
Function Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes . Plays a role in granulocyte differentiation . Isoform 2 functions as an A-kinase-anchoring protein .
Cellular Localization Isoform 1: Nucleus, nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.. Isoform 2: Nucleus, nucleoplasm Golgi apparatus membrane
Tissue Specificity Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
Swiss-Prot Key

 

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