Anti-EZH2 Antibody

Rs. 61,689.00
SKU stj27486

General Information

Product name Anti-EZH2 Antibody
Short Description Rabbit polyclonal to EZH2
Description This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Applications WB,IHC,IF,FC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
IF 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-EZH2 Antibody
Immunogen Recombinant protein of human EZH2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 85.4 kDa
Database Links
Alternative Names EZH2Histone-lysine N-methyltransferase EZH2 EZH2 antibodyKMT6
Function Polycomb group (PcG) protein, Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene, Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively, Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 , Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation, The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems, Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes, EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA, Regulates the circadian clock via histone methylation at the promoter of the circadian genes, Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer
Cellular Localization Nucleus
Tissue Specificity Expressed in many tissues, overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.
Swiss-Prot Key

 

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