Anti-FBXO32 Antibody

Rs. 61,689.00
SKU stj28908

General Information

Product name Anti-FBXO32 Antibody
Short Description Rabbit polyclonal to FBXO32
Description This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-FBXO32 Antibody
Immunogen A synthetic peptide of human FBXO32
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 41.6 kDa
Database Links
Alternative Names FBXO32F-box only protein 32 antibodyAtrogin-1 antibodyMuscle atrophy F-box protein antibodyMAFbxFBXO32
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy, Recognizes TERF1.
Cellular Localization Cytoplasm.
Tissue Specificity Specifically expressed in cardiac and skeletal muscle
Swiss-Prot Key

 

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