Anti-FBXW11 Antibody

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Rs. 34,800.00
Rs. 32,800.00
SKU stj110094

General Information

Product name Anti-FBXW11 Antibody
Short Description Rabbit polyclonal to FBXW11
Description This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box/WD repeat-containing protein 1BHomologous to Slimb proteinHOS
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human FBXW11 (NP_387448.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 62.1 kDa
Database Links
Alternative Names FBXW11F-box/WD repeat-containing protein 11 antibodyF-box and WD repeats protein beta-TrCP2 antibodyF-box/WD repeat-containing protein 1B antibodyHomologous to Slimb protein antibodyHOSFBXW11 antibodyBTRCP2 antibodyFBW1B antibodyFBXW1B antibodyKIAA0696
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Probably recognizes and binds to phosphorylated target proteins, SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling, SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription, SCF(FBXW11) mediates the ubiquitination of IFNAR1, SCF(FBXW11) mediates the ubiquitination of CEP68
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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