Anti-FCGR2B Antibody

Rs. 45,619.00
SKU stj29692

General Information

Product name Anti-FCGR2B Antibody
Short Description Rabbit polyclonal to FCGR2B
Description The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-FCGR2B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 241-310 of human FCGR2B (NP_003992.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34 kDa
Database Links
Alternative Names FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b antibodyIgG Fc receptor II-b antibodyCDw32 antibodyFc-gamma RII-b antibodyFc-gamma-RIIb antibodyFcRII-b antibodyCD antigen CD32FCGR2B antibodyCD32 antibodyFCG2 antibodyIGFR2
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma, Low affinity receptor, Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells, Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor, Isoform IIB1 fails to mediate endocytosis or phagocytosis, Isoform IIB2 does not trigger phagocytosis
Cellular Localization Cell membrane
Tissue Specificity Is the most broadly distributed fc-gamma-receptor, expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, langerhans cells, b-cells, platelets cells and placenta (endothelial cells), not detected in natural killer cells
Swiss-Prot Key

 

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