Anti-FGG Antibody

Rs. 45,619.00
SKU stj27609

General Information

Product name Anti-FGG Antibody
Short Description Rabbit polyclonal to FGG
Description The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-FGG Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-330 of human FGG (NP_000500.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.5 kDa
Database Links
Alternative Names FGGFibrinogen gamma chainFGG antibodyPRO2061
Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix, Has a major function in hemostasis as one of the primary components of blood clots, In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization, Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood, However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo, Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway, Maternal fibrinogen is essential for successful pregnancy, Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage, May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Localization Secreted
Tissue Specificity Detected in blood plasma (at protein level).
Swiss-Prot Key

 

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