Anti-FGR Antibody

Rs. 68,577.00
SKU stj70074

General Information

Product name Anti-FGR Antibody
Short Description Goat polyclonal to FGR
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-FGR Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 59.5 kDa
Database Links
Alternative Names FGRTyrosine-protein kinase Fgr FGR antibodySRC2
Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration, Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis, Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B, Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion, Depending on the context, activates or inhibits cellular responses, Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes, Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages, Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation, Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling, Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol, Promotes activation of PIK3R1, Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization, Phosphorylates ABL1, Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2, Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1,
Cellular Localization Cell membrane,
Tissue Specificity Detected in neutrophils, monocytes and natural killer cells (at protein level), detected in monocytes and large lymphocytes,
Swiss-Prot Key

 

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