Anti-FIP1L1 Antibody

Rs. 45,619.00
SKU stj29218

General Information

Product name Anti-FIP1L1 Antibody
Short Description Rabbit polyclonal to FIP1L1
Description This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name Anti-FIP1L1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 66.5 kDa
Database Links
Alternative Names FIP1L1Pre-mRNA 3'-end-processing factor FIP1 antibodyhFip1 antibodyFIP1-like 1 protein antibodyFactor interacting with PAP antibodyRearranged in hypereosinophiliaFIP1L1 antibodyFIP1 antibodyRHE
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition, Binds to U-rich RNA sequence elements surrounding the poly(A) site, May act to tether poly(A) polymerase to the CPSF complex.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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