Anti-FKBP8 Antibody

Rs. 45,619.00
SKU stj29165

General Information

Product name Anti-FKBP8 Antibody
Short Description Rabbit polyclonal to FKBP8
Description The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-FKBP8 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP8 (NP_036313.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 44.6 kDa
Database Links
Alternative Names FKBP8Peptidyl-prolyl cis-trans isomerase FKBP8 antibodyPPIase FKBP8FKBP8 antibodyFKBP38
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium, Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state, The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets, The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Cellular Localization Mitochondrion
Tissue Specificity Widely expressed, highest levels seen in the brain, highly abundant in the retina.
Swiss-Prot Key

 

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