Anti-FLT4 Antibody

Rs. 45,619.00
SKU stj27572

General Information

Product name Anti-FLT4 Antibody
Short Description Rabbit polyclonal to FLT4
Description This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-FLT4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1174-1363 of human FLT4 (NP_891555.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 152.8 kDa
Database Links
Alternative Names FLT4Vascular endothelial growth factor receptor 3 antibodyVEGFR-3FLT4 antibodyVEGFR3
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development, Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting, Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling, Modulates KDR signaling by forming heterodimers, The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis, Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades
Cellular Localization Cell membrane
Tissue Specificity Detected in endothelial cells (at protein level), widely expressed, detected in fetal spleen, lung and brain, detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.
Swiss-Prot Key

 

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