Anti-FMR1 Antibody

Rs. 45,619.00
SKU stj27612

General Information

Product name Anti-FMR1 Antibody
Short Description Rabbit polyclonal to FMR1
Description The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-FMR1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human FMR1 (NP_001172011.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 71.2 kDa
Database Links
Alternative Names FMR1Synaptic functional regulator FMR1 antibodyFragile X mental retardation protein 1 antibodyFMRP antibodyProtein FMR-1FMR1
Function Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs components.
Cellular Localization Nucleus, Isoform 11: Nucleus
Tissue Specificity Expressed in the brain, cerebellum and testis.
Swiss-Prot Key

 

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