Anti-FOLR1 Antibody

Rs. 61,689.00
SKU stj23684

General Information

Product name Anti-FOLR1 Antibody
Short Description Rabbit polyclonal to FOLR1
Description The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Applications WB,IHC,FC
Dilution range WB,1:500 - 1:1000|IHC,1:50 - 1:100|FC,1:20 - 1:50
Protein Name Anti-FOLR1 Antibody
Immunogen A synthetic peptide of human FOLR1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 29.8 kDa
Database Links
Alternative Names FOLR1Folate receptor alpha antibodyFR-alpha antibodyAdult folate-binding protein antibodyFBP antibodyFolate receptor 1 antibodyFolate receptor antibodyadult antibodyKB cells FBP antibodyOvarian tumor-associated antigen MOv18FOLR1 antibodyFOLR
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells, Has high affinity for folate and folic acid analogs at neutral pH, Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release, Required for normal embryonic development and normal cell proliferation.
Cellular Localization Cell membrane
Tissue Specificity Primarily expressed in tissues of epithelial origin, expression is increased in malignant tissues, expressed in kidney, lung and cerebellum, detected in placenta and thymus epithelium.
Swiss-Prot Key

 

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