Anti-Foxa2 Antibody

Rs. 61,689.00
SKU stj27950

General Information

Product name Anti-Foxa2 Antibody
Short Description Rabbit polyclonal to FOXA2
Description This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
IF 1:20 - 1:100
Protein Name Anti-Foxa2 Antibody
Immunogen A synthetic peptide of human FOXA2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.3 kDa
Database Links
Alternative Names FOXA2Hepatocyte nuclear factor 3-beta antibodyHNF-3-beta antibodyHNF-3B antibodyForkhead box protein A2 antibodyTranscription factor 3B antibodyTCF-3BFOXA2 antibodyHNF3B antibodyTCF3B
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), In embryonic development is required for notochord formation, Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs
Cellular Localization Nucleus, in response to insulin signaling via AKT1 is exported from the nucleus
Tissue Specificity
Swiss-Prot Key

 

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