Anti-FOXP2 Antibody

Rs. 45,619.00
SKU stj27644

General Information

Product name Anti-FOXP2 Antibody
Short Description Rabbit polyclonal to FOXP2
Description This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-FOXP2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 441-740 of human FOXP2 (NP_683696.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 79.9 kDa
Database Links
Alternative Names FOXP2Forkhead box protein P2 antibodyCAG repeat protein 44 antibodyTrinucleotide repeat-containing gene 10 proteinFOXP2 antibodyCAGH44 antibodyTNRC10
Function Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium, May also play a role in developing neural, gastrointestinal and cardiovascular tissues, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential, Plays a role in synapse formation by regulating SRPX2 levels, Involved in neural mechanisms mediating the development of speech and language
Cellular Localization Nucleus
Tissue Specificity Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.
Swiss-Prot Key

 

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