Anti-FOXP3 Antibody

Rs. 45,619.00
SKU stj27673

General Information

Product name Anti-FOXP3 Antibody
Short Description Rabbit polyclonal to FOXP3
Description The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-FOXP3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human FOXP3 (NP_001107849.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 47.2 kDa
Database Links
Alternative Names FOXP3Forkhead box protein P3 antibodyScurfinFOXP3 antibodyIPEX antibodyJM2
Function Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells, Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases, The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG), Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.
Cellular Localization Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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