Anti-Frizzled-5 antibody

Rs. 50,211.00
SKU stj93146

General Information

Product name Anti-Frizzled-5 antibody
Short Description
Description Rabbit polyclonal to Frizzled-5.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Frizzled-5 antibody
Immunogen Synthesized peptide derived from human Frizzled-5
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 65 kDa
Database Links
Alternative Names Frizzled-5 antibody
Fz-5 antibody
hFz5 antibody
FzE5 antibody
C2orf31 antibody
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.
Cellular Localization Cell membrane Golgi apparatus membrane. Localized at the plasma membrane and also found at the Golgi.
Tissue Specificity
Swiss-Prot Key

 

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