General Information
| Product name | Anti-Frizzled-5 antibody |
|---|---|
| Short Description | |
| Description | Rabbit polyclonal to Frizzled-5. |
| Applications | WB,IHC,IF,ELISA |
| Dilution range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Protein Name | Anti-Frizzled-5 antibody |
| Immunogen | Synthesized peptide derived from human Frizzled-5 |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 65 kDa |
| Database Links | |
| Alternative Names | Frizzled-5 antibody Fz-5 antibody hFz5 antibody FzE5 antibody C2orf31 antibody |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway. |
| Cellular Localization | Cell membrane Golgi apparatus membrane. Localized at the plasma membrane and also found at the Golgi. |
| Tissue Specificity | |
| Swiss-Prot Key |