Anti-FRZB Antibody

Rs. 45,619.00
SKU stj28675

General Information

Product name Anti-FRZB Antibody
Short Description Rabbit polyclonal to FRZB
Description The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:10 - 1:100
Protein Name Anti-FRZB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 166-325 of human FRZB (NP_001454.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.3 kDa
Database Links
Alternative Names FRZBSecreted frizzled-related protein 3 antibodysFRP-3 antibodyFrezzled antibodyFritz antibodyFrizzled-related protein 1 antibodyFrzB-1FRZB antibodyFIZ antibodyFRE antibodyFRP antibodyFRZB1 antibodySFRP3
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts, They have a role in regulating cell growth and differentiation in specific cell types, SFRP3/FRZB appears to be involved in limb skeletogenesis, Antagonist of Wnt8 signaling, Regulates chondrocyte maturation and long bone development
Cellular Localization Secreted
Tissue Specificity Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks), at 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones, highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas, weakly expressed in lung and liver
Swiss-Prot Key

 

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