Anti-FUBP1 Antibody

Rs. 45,619.00
SKU stj27556

General Information

Product name Anti-FUBP1 Antibody
Short Description Rabbit polyclonal to FUBP1
Description The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-FUBP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 302-644 of human FUBP1 (NP_003893.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 67.6 kDa
Database Links
Alternative Names FUBP1Far upstream element-binding protein 1 antibodyFBP antibodyFUSE-binding protein 1 antibodyDNA helicase V antibodyhDH VFUBP1
Function Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter, May act both as activator and repressor of transcription.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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