Anti-FYN Antibody

Rs. 68,577.00
SKU stj70057

General Information

Product name Anti-FYN Antibody
Short Description Goat polyclonal to FYN
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-FYN Antibody
Immunogen N Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 60.8 kDa
Database Links
Alternative Names FYNTyrosine-protein kinase Fyn FYN
Function Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance, Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain, Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions, Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin), Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT, Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage, Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6, Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein, Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation, Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation, Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts, CSK maintains LCK and FYN in an inactive form, Promotes CD28-induced phosphorylation of VAV1,
Cellular Localization Cytoplasm, Nucleus, Cell membrane,
Tissue Specificity Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially t-lymphocytes,
Swiss-Prot Key

 

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