Anti-FZD8 Antibody

Rs. 68,577.00
SKU stj70823

General Information

Product name Anti-FZD8 Antibody
Short Description Goat polyclonal to FZD8
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-FZD8 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 73.3 kDa
Database Links
Alternative Names FZD8Frizzled-8 antibodyFz-8 antibodyhFz8FZD8
Function Receptor for Wnt proteins, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes, The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes, A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, Both pathways seem to involve interactions with G-proteins, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Coreceptor along with RYK of Wnt proteins, such as WNT1,
Cellular Localization Membrane
Tissue Specificity Most abundant in fetal kidney, followed by brain and lung, in adult tissues, expressed in kidney, heart, pancreas and skeletal muscle
Swiss-Prot Key

 

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