Anti-GANP antibody

Rs. 50,211.00
SKU stj93212

General Information

Product name Anti-GANP antibody
Short Description
Description Rabbit polyclonal to GANP.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-GANP antibody
Immunogen Synthesized peptide derived from human GANP
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 218 kDa
Database Links
Alternative Names Germinal-center associated nuclear protein antibody
80 kDa MCM3-associated protein antibody
MCM3 acetylating protein antibody
MCM3 acetyltransferase antibody
KIAA0572 antibody
MAP80 antibody
Function Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells . Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.
Cellular Localization Isoform GANP: Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene. Isoform MCM3AP: Cytoplasm Nucleus, nucleoplasm. Binding to MCM3 is required for nuclear import, associates with chromatin.
Tissue Specificity
Swiss-Prot Key

 

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