Anti-GCK Antibody

Rs. 61,689.00
SKU stj23761

General Information

Product name Anti-GCK Antibody
Short Description Rabbit polyclonal to GCK
Description Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Applications WB,IHC,IF
Dilution range WB 1:200 - 1:500
IHC 1:50 - 1:100
IF 1:20 - 1:50
Protein Name Anti-GCK Antibody
Immunogen A synthetic peptide of human GCK
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.2 kDa
Database Links
Alternative Names GCKGlucokinase GCK
Function Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration, Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant, The role of GCK is to provide G6P for the synthesis of glycogen, Pancreatic glucokinase plays an important role in modulating insulin secretion, Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Cellular Localization Cytoplasm
Tissue Specificity Isoform 1 is expressed in pancreas, isoform 2 and isoform 3 is expressed in liver
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF