Anti-GCKR Antibody

Rs. 45,619.00
SKU stj27645

General Information

Product name Anti-GCKR Antibody
Short Description Rabbit polyclonal to GCKR
Description This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-GCKR Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCKR (NP_001477.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 68.7 kDa
Database Links
Alternative Names GCKRGlucokinase regulatory protein antibodyGKRP antibodyGlucokinase regulatorGCKR
Function Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme, The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Cellular Localization Cytoplasm.
Tissue Specificity Found in liver and pancreas, not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
Swiss-Prot Key

 

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