Anti-GLUD1 Antibody

Rs. 45,619.00
SKU stj29946

General Information

Product name Anti-GLUD1 Antibody
Short Description Rabbit polyclonal to GLUD1
Description This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
Protein Name Anti-GLUD1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 54-240 of human GLUD1 (NP_005262.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 61.4 kDa
Database Links
Alternative Names GLUD1Glutamate dehydrogenase 1 antibodymitochondrial antibodyGDH 1GLUD1 antibodyGLUD
Function Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate, Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle, May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Cellular Localization Mitochondrion matrix
Tissue Specificity
Swiss-Prot Key

 

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