Anti-GMNN Antibody

Rs. 45,619.00
SKU stj27269

General Information

Product name Anti-GMNN Antibody
Short Description Rabbit polyclonal to GMNN
Description This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-GMNN Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human GMNN (NP_056979.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.6 kDa
Database Links
Alternative Names GMNNGemininGMNN
Function Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC), It is degraded during the mitotic phase of the cell cycle, Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle
Cellular Localization Cytoplasm, Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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