Anti-GPI Antibody

Rs. 45,619.00
SKU stj28996

General Information

Product name Anti-GPI Antibody
Short Description Rabbit polyclonal to GPI
Description This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-GPI Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human GPI (NP_000166.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 63.1 kDa
Database Links
Alternative Names GPIGlucose-6-phosphate isomerase antibodyGPIGPI
Function Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility, GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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