Anti-GRB10 Antibody

Rs. 68,577.00
SKU stj71530

General Information

Product name Anti-GRB10 Antibody
Short Description Goat polyclonal to GRB10
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-GRB10 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 67.2 kDa
Database Links
Alternative Names GRB10Growth factor receptor-bound protein 10 antibodyGRB10 adapter protein antibodyInsulin receptor-binding protein Grb-IRGRB10 antibodyGRBIR antibodyKIAA0207
Function Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways, Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors, The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation, Delays and reduces AKT1 phosphorylation in response to insulin stimulation, Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation, Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways, May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation, Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6, Positive regulator of the KDR/VEGFR-2 signaling pathway, May inhibit NEDD4-mediated degradation of KDR/VEGFR-2,
Cellular Localization Cytoplasm,
Tissue Specificity Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain,
Swiss-Prot Key

 

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