Anti-GRIK2 Antibody

Rs. 45,619.00
SKU stj23862

General Information

Product name Anti-GRIK2 Antibody
Short Description Rabbit polyclonal to GRIK2
Description Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-GRIK2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human GRIK2 (NP_068775.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 102.6 kDa
Database Links
Alternative Names GRIK2Glutamate receptor ionotropic antibodykainate 2 antibodyGluK2 antibodyExcitatory amino acid receptor 4 antibodyEAA4 antibodyGlutamate receptor 6 antibodyGluR-6 antibodyGluR6GRIK2 antibodyGLUR6
Function Ionotropic glutamate receptor, L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system, Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse, The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Cellular Localization Cell membrane
Tissue Specificity Expression is higher in cerebellum than in cerebral cortex
Swiss-Prot Key

 

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