Anti-GSDMB Antibody

Rs. 45,619.00
SKU stj29610

General Information

Product name Anti-GSDMB Antibody
Short Description Rabbit polyclonal to GSDMB
Description This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-GSDMB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GSDMB (NP_001159431.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.8 kDa
Database Links
Alternative Names GSDMBGasdermin-B antibodyGasdermin-like proteinGSDMB antibodyGSDML antibodyPP4052 antibodyPRO2521
Function The N-terminal moiety promotes pyroptosis, May be acting by homooligomerizing within the membrane and forming pores.
Cellular Localization Cytoplasm
Tissue Specificity In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
Swiss-Prot Key

 

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