Anti-GSTM4 Antibody

Rs. 45,619.00
SKU stj29570

General Information

Product name Anti-GSTM4 Antibody
Short Description Rabbit polyclonal to GSTM4
Description Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-GSTM4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human GSTM4 (NP_000841.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 25.6 kDa
Database Links
Alternative Names GSTM4Glutathione S-transferase Mu 4 GSTM4
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles, Active on 1-chloro-2,4-dinitrobenzene
Cellular Localization Cytoplasm
Tissue Specificity Expressed in a wide variety of tissues
Swiss-Prot Key

 

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