Anti-GTF2H3 Antibody

Rs. 45,619.00
SKU stj29268

General Information

Product name Anti-GTF2H3 Antibody
Short Description Rabbit polyclonal to GTF2H3
Description This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-GTF2H3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-308 of human GTF2H3 (NP_001507.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34.4 kDa
Database Links
Alternative Names GTF2H3General transcription factor IIH subunit 3 antibodyBasic transcription factor 2 34 kDa subunit antibodyBTF2 p34 antibodyGeneral transcription factor IIH polypeptide 3 antibodyTFIIH basal transcription factor complex p34 subunitGTF2H3
Function Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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