Anti-GZMB Antibody

Rs. 45,619.00
SKU stj26211

General Information

Product name Anti-GZMB Antibody
Short Description Rabbit polyclonal to GZMB
Description Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-GZMB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 148-247 of human GZMB (NP_004122.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 27.7 kDa
Database Links
Alternative Names GZMBGranzyme B GZMB antibodyCGL1 antibodyCSPB antibodyCTLA1 antibodyGRB
Function This enzyme is necessary for target cell lysis in cell-mediated immune responses, It cleaves after Asp, Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution, Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
Cellular Localization Cytoplasmic granule.
Tissue Specificity
Swiss-Prot Key

 

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