Anti-HAND2 Antibody

Rs. 45,619.00
SKU stj29124

General Information

Product name Anti-HAND2 Antibody
Short Description Rabbit polyclonal to HAND2
Description The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-HAND2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human HAND2 (NP_068808.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.7 kDa
Database Links
Alternative Names HAND2Heart- and neural crest derivatives-expressed protein 2 antibodyClass A basic helix-loop-helix protein 26 antibodybHLHa26 antibodyDeciduum antibodyheart antibodyautonomic nervous system and neural crest derivatives-expressed protein 2 antibodydHANDHAND2 antibodyBHLHA26 antibodyDHAND
Function Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries, Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway, Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud, Is involved in the development of branchial arches, which give rise to unique structures in the head and neck, Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Cellular Localization Nucleus
Tissue Specificity Heart
Swiss-Prot Key

 

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