Anti-HAX1 Antibody

Rs. 45,619.00
SKU stj27497

General Information

Product name Anti-HAX1 Antibody
Short Description Rabbit polyclonal to HAX1
Description The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100
Protein Name Anti-HAX1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-279 of human HAX1 (NP_006109.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 31.6 kDa
Database Links
Alternative Names HAX1HCLS1-associated protein X-1 antibodyHS1-associating protein X-1 antibodyHAX-1 antibodyHS1-binding protein 1 antibodyHSP1BP-1HAX1 antibodyHS1BP1
Function Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex , Promotes GNA13-mediated cell migration, Involved in the clathrin-mediated endocytosis pathway, May be involved in internalization of ABC transporters such as ABCB11, May inhibit CASP9 and CASP3, Promotes cell survival, May regulate intracellular calcium pools.
Cellular Localization Mitochondrion.
Tissue Specificity Ubiquitous, up-regulated in oral cancers.
Swiss-Prot Key

 

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