Anti-HDAC3 Antibody

Rs. 50,211.00
SKU stj29889

General Information

Product name Anti-HDAC3 Antibody
Short Description Mouse monoclonal to HDAC3
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Applications WB,ICC
Dilution range WB 1:500 - 1:2000
ICC 1:200 - 1:500
Protein Name Anti-HDAC3 Antibody
Immunogen Recombinant protein of human HDAC3
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.8 kDa
Database Links
Alternative Names HDAC3Histone deacetylase 3 antibodyHD3HDAC3
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates, Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression, Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1
Cellular Localization Nucleus.
Tissue Specificity Widely expressed
Swiss-Prot Key

 

You recently viewed

Clear recently viewed