Anti-HDAC4 Antibody

Rs. 45,619.00
SKU stj29788

General Information

Product name Anti-HDAC4 Antibody
Short Description Rabbit polyclonal to HDAC4
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-HDAC4 Antibody
Immunogen A synthetic peptide of human HDAC4
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 119 kDa
Database Links
Alternative Names HDAC4Histone deacetylase 4 antibodyHD4HDAC4 antibodyKIAA0288
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D, Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer, Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity Ubiquitous
Swiss-Prot Key

 

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