Anti-HDAC7 Antibody

Rs. 45,619.00
SKU stj29424

General Information

Product name Anti-HDAC7 Antibody
Short Description Rabbit polyclonal to HDAC7
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-HDAC7 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HDAC7 (NP_056216.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 102.9 kDa
Database Links
Alternative Names HDAC7Histone deacetylase 7 antibodyHD7HDAC7 antibodyHDAC7A
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C, During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity), May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene, Positively regulates the transcriptional repressor activity of FOXP3.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

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