Anti-HDAC8 Antibody

Rs. 45,619.00
SKU stj28392

General Information

Product name Anti-HDAC8 Antibody
Short Description Rabbit polyclonal to HDAC8
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-HDAC8 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human HDAC8 (NP_060956.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 41.8 kDa
Database Links
Alternative Names HDAC8Histone deacetylase 8 antibodyHD8HDAC8 antibodyHDACL1 antibodyCDA07
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin, May play a role in smooth muscle cell contractility.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity Weakly expressed in most tissues, expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
Swiss-Prot Key

 

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