Anti-HIF1A Antibody

Rs. 45,619.00
SKU stj28187

General Information

Product name Anti-HIF1A Antibody
Short Description Rabbit polyclonal to HIF1A
Description This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-HIF1A Antibody
Immunogen A synthetic peptide of human HIF1A
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 92.7 kDa
Database Links
Alternative Names HIF1AHypoxia-inducible factor 1-alpha antibodyHIF-1-alpha antibodyHIF1-alpha antibodyARNT-interacting protein antibodyBasic-helix-loop-helix-PAS protein MOP1 antibodyClass E basic helix-loop-helix protein 78 antibodybHLHe78 antibodyMember of PAS protein 1 antibodyPAS domain-containing protein 8HIF1A antibodyBHLHE78 antibodyMOP1 antibodyPASD8
Function Functions as a master transcriptional regulator of the adaptive response to hypoxia, Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia, Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease, Heterodimerizes with ARNT
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in most tissues with highest levels in kidney and heart, overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors, a higher level expression seen in pituitary tumors as compared to the pituitary gland.
Swiss-Prot Key

 

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