Anti-Histone Deacetylase 1 Antibody

Rs. 68,577.00
SKU stj70893

General Information

Product name Anti-Histone Deacetylase 1 Antibody
Short Description Goat polyclonal to Histone Deacetylase 1
Description
Applications ELISA, WB, ChIP
Dilution range
Protein Name Anti-Histone Deacetylase 1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 55.1 kDa
Database Links
Alternative Names HDAC1Histone deacetylase 1 antibodyHD1HDAC1 antibodyRPD3L1
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Deacetylates SP proteins, SP1 and SP3, and regulates their function, Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons, Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation, Deacetylates TSHZ3 and regulates its transcriptional repressor activity, Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B, Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer, Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation,
Cellular Localization Nucleus
Tissue Specificity Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain
Swiss-Prot Key

 

You recently viewed

Clear recently viewed