Anti-HMG-2 antibody

Rs. 50,211.00
SKU stj93552

General Information

Product name Anti-HMG-2 antibody
Short Description
Description Rabbit polyclonal to HMG-2.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-HMG-2 antibody
Immunogen Synthesized peptide derived from human HMG-2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 27 kDa
Database Links
Alternative Names High mobility group protein B2 antibody
High mobility group protein 2 antibody
HMG2 antibody
Function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity . Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) . Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors . In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE . Has antimicrobial activity in gastrointestinal epithelial tissues . Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity . Involved in modulation of neurogenesis probably by regulation of neural stem proliferation . Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway .
Cellular Localization Nucleus Chromosome Cytoplasm Secreted. In basal state predominantly nuclear.
Tissue Specificity Expressed in gastric and intestinal tissues (at protein level).
Swiss-Prot Key

 

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