Anti-hnRNP Q antibody

Rs. 50,211.00
SKU stj93571

General Information

Product name Anti-hnRNP Q antibody
Short Description
Description Rabbit polyclonal to hnRNP Q.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-hnRNP Q antibody
Immunogen Synthesized peptide derived from human hnRNP Q
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 62 kDa
Database Links
Alternative Names Heterogeneous nuclear ribonucleoprotein Q antibody
Glycine- and tyrosine-rich RNA-binding protein antibody
GRY-RBP antibody
NS1-associated protein 1 antibody
Synaptotagmin-binding, cytoplasmic RNA-interacting protein antibody
HNRPQ antibody
NSAP1 antibody
Function Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
Cellular Localization Cytoplasm Microsome Endoplasmic reticulum Nucleus. The tyrosine phosphorylated form bound to RNA is found in microsomes . Localized in cytoplasmic mRNP granules containing untranslated mRNAs . Isoform 1: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm. Isoform 2: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm. Isoform 3: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm.
Tissue Specificity Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
Swiss-Prot Key

 

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