Anti-HRI antibody

Rs. 50,211.00
SKU stj93592

General Information

Product name Anti-HRI antibody
Short Description
Description Rabbit polyclonal to HRI.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-HRI antibody
Immunogen Synthesized peptide derived from human HRI
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 71 kDa
Database Links
Alternative Names Eukaryotic translation initiation factor 2-alpha kinase 1 antibody
Heme-controlled repressor antibody
HCR antibody
Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody
Heme-regulated inhibitor antibody
Hemin-sensitive initiation factor 2-alpha kinase antibody
KIAA1369 antibody
PRO1362 antibody
Function Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions .
Cellular Localization Cytoplasm
Tissue Specificity Expressed predominantly in erythroid cells. At much lower levels, expressed in hepatocytes (at protein level).
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF